Welcome to the Mentzer Lab

A focus of our laboratory is the adaptive and regenerative processes contributing to tissue repair and regeneration. These processes typically involve blood vessel growth (angiogenesis) and changes in the organ surface (mesothelial-mesenchymal transition). The study of these processes involves a multi-scale approach: 1) the regulated expression of genes and molecules, 2) the interactive signaling communication between cells, and 3) the structural/biomechanical relationships leading to adult tissue remodeling (morphogenesis). A recent focus of our approach has been the use of biologic polymers(such as pectin) as tools to explore mesothelial-mesenchymal transition and other fundamental processes essential to normal tissue repair and regeneration. The perturbation of these processes is a major contributor to lung disease and lung cancer.

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We are accepting applications for a funded Surgical Research Fellowship (US Citizens or equivalent currently in an American surgical residency) beginning in July 2023. Competitive Fellowships are also available starting July 2024. Contact us for details.
Aditi Gore presented “Interfacial Mechanics of Multi-Ply High Methoxyl Citrus Pectin Films as Visceral Organ Injury Sealants" at the American Medical Association Research Challenge October 21-23, 2021.
Sarah Southerland and Steven Burcat won the grand prize in the Design of Medical Devices conference for the team's creative pectin application device.
Dr. Yifan Zheng was planning to present "Branch-chain interpenetration of the mesothelial glycoclayx with naturally-occurring biopolymers" at Experimental Biology in San Diego on April 7, 2020.
Christine Byun presented "Optimizing the physical properties of pectin for application as a visceral organ sealant" at the Academic Surgical Congress in Orlando, FL on February 6, 2020.
Dr. Yifan Zheng will be presenting "Branch-chain interpenetration of the mesothelial glycoclayx with naturally-occurring biopolymers" at Experimental Biology in San Diego on April 7, 2020.
Christine Byun presented "Optimizing the physical properties of pectin for application as a visceral organ sealant" at the Academic Surgical Congress in Orlando, FL on February 6, 2020.
Christine Byun will be presenting her work at the AMA EXPO Research Symposium on November 15, 2019.
Sarah Southerland and Steven Burcat won the grand prize in the Design of Medical Devices conference for the team's creative pectin application device.